Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Nuclear Biology & Nuclear Chemistry Aproaches - Structural Fragility and Replication Dynamics Near the ERG11 Subtelomeric Region in Candida albicans - Non-Elaborate Posts - Post 8

 Spatial genome organization further shapes repair dynamics. ERG11 relocates toward the nuclear periphery during stress, entering regions rich in nuclear pore-associated repair foci. This relocalization enhances contact with Rad52p and Mre11p complexes, effectively coupling repair efficiency to nuclear geography (Finkel et al., 2021). The nuclear periphery provides a microenvironment optimized for DNA repair through enriched ATPase and oxidoreductase activity. Consequently, nuclear space itself becomes an active participant in mutation generation: the proximity to repair hubs ensures that damage is neither ignored nor perfectly corrected, but rather reconfigured in a way that preserves function while introducing diversity

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