Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Nuclear Biology & Nuclear Chemistry Aproaches - Chromatin Accessibility, Nuclear Chemistry, and Mutation Propensity of the ERG11 Locus in Candida albicans - Non-Elaborate Posts - Post 7

 Redox chemistry profoundly shapes histone behavior through oxidative post-translational modifications. Under azole-induced stress, ROS alter cysteine thiols on histones and chromatin remodelers, changing their binding affinities and enzymatic rates (Puig & Gutiérrez, 2022). Oxidative carbonylation of H3 and H4 impairs nucleosome stability, promoting transient accessibility near ERG11. This redox-driven chromatin softening coincides with increased heme synthesis and redistribution, creating a nuclear chemical loop that connects ergosterol metabolism with chromatin plasticity. The nuclear environment thus behaves as a redox-sensitive organelle, wherein chemical oxidation and chromatin fluidity exist in mutual regulation.

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