Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Nuclear Biology & Nuclear Chemistry Aproaches - Chromatin Accessibility, Nuclear Chemistry, and Mutation Propensity of the ERG11 Locus in Candida albicans - Non-Elaborate Posts - Post 5

 When chromatin opens for transcription, it simultaneously exposes DNA to damage and replication stress. Highly transcribed genes such as ERG11 during drug challenge experience transcription-replication conflicts that produce localized double-strand breaks (Anderson et al., 2015). RNA polymerase stalling, R-loop accumulation, and torsional stress contribute to mutagenic events near the promoter and coding sequence. In subtelomeric chromatin, where repair fidelity is compromised, such transcription-associated damage becomes a principal driver of adaptive mutations. Thus, chromatin accessibility — while essential for gene expression — paradoxically becomes the architect of genomic plasticity.

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