Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Nuclear Biology & Nuclear Chemistry Aproaches - Chromatin Accessibility, Nuclear Chemistry, and Mutation Propensity of the ERG11 Locus in Candida albicans - Non-Elaborate Posts - Post 4

 The link between metabolism and chromatin extends beyond substrate availability. Fluctuations in mitochondrial activity, glycolytic flux, and oxidative stress alter nuclear NADH/NAD+ and acetyl-CoA ratios, shifting the balance between histone acetylation and deacetylation. During azole treatment, the inhibition of ergosterol synthesis perturbs membrane integrity and induces mitochondrial oxidative signaling, indirectly modifying nuclear metabolic profiles (Puig & Gutiérrez, 2022). Elevated NADH suppresses Sir2p activity, relaxing telomeric heterochromatin and permitting ERG11 activation. Consequently, antifungal stress translates into a metabolic signal that chemically reprograms chromatin accessibility, establishing a direct conduit between nuclear chemistry and adaptive mutagenesis.

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