Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Nuclear Biology & Nuclear Chemistry Aproaches - Structural Fragility and Replication Dynamics Near the ERG11 Subtelomeric Region in Candida albicans - Non-Elaborate Posts - Post 4

 Unlike the high-fidelity HR that dominates nuclear cores, error-prone repair in subtelomeric DNA serves an adaptive function. NHEJ and MMEJ both rely on minimal sequence homology to bridge DNA ends, and in doing so, they introduce base mismatches or frameshifts that can fine-tune enzyme structure. In the case of ERG11, even single amino acid substitutions such as Y132F or G464S, arising from imperfect repair synthesis, profoundly affect the steric and electrostatic configuration of the azole-binding pocket (Flowers et al., 2015). These repair-induced mutations exemplify an evolutionary paradox: damage correction simultaneously produces innovation. In effect, C. albicans has co-opted the chemistry of repair as a genetic accelerator, translating nuclear instability into biochemical resilience.

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