Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Nuclear Biology & Nuclear Chemistry Aproaches - Structural Fragility and Replication Dynamics Near the ERG11 Subtelomeric Region in Candida albicans - Non-Elaborate Posts - Post 6

Subtelomeric regions like those surrounding ERG11 often experience replication fork collapse due to DNA secondary structures such as G-quadruplexes. The ATR/Mec1 checkpoint pathway responds to this replication stress by stabilizing stalled forks and recruiting repair factors. Yet, persistent stalling can provoke template switching and break-induced replication, mechanisms that promote copy number variation and sequence heterogeneity (Finkel et al., 2021). In the nuclear chemistry of C. albicans, replication stress thus becomes an active agent of diversification. This feedback between replication and repair establishes a self-reinforcing cycle of structural instability, ensuring that ERG11 remains a genetically responsive locus capable of rapid evolutionary tuning.

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