Viruses - Noroviruses - Structure Of The Norovirys Biological Particles - Post 1

 ORF1 encodes a large polyprotein that is co- and post-translationally cleaved by the virus’s own 3C-like protease into six non-structural proteins (NS1/2, NS3, NS4, VPg/NS5, NS6, and NS7). These proteins coordinate viral RNA replication, genome linkage (via VPg), and replication machinery catalysis (via RNA-dependent RNA polymerase).

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